Availability of high-speed internet and smartphones provides a relatively inexpensive and easy to use platform for promoting physical activity and a healthier lifestyle among a large portion of population. This study aimed to investigate the efficacy of internet-delivered computer-tailored multimedia advice through smartphones on physical activity and quality of life among healthy individuals. This study was a 12-week long randomized clinical trial. 155 healthy volunteers were randomly divided into intervention (n=76) and control (n=79) groups. Intervention group received weekly tailored exercise programs in multimedia format via Telegram® messenger on their smartphones. They were required to fill an online workbook every week and received suitable feedbacks based on their weekly activity. Control group had access to a general 12-week exercise program from the beginning. Intervention group showed a 168.814 (75.456-262.171) (95% CI) METs.min/week increase in total physical activity (p=0.001) and 11.2 (7.54-14.99) minutes/week increase in moderate to vigorous physical activity (p<0.001) compared to baseline. Statistically significant improvements in several domains of quality of life were observed in intervention group compared to the control group. It seems that combination of internet and smartphones is useful as a relatively inexpensive tool to increase physical activity and quality of life among healthy individuals.