Introduction: Orlistat or fat-stop is among the synthetic drugs and slim quick is one of the popular herbal remedies used for obesity and overweight. The aim of this study was to investigate the effects of slim quick and fat-stop synthetic drug and comparing their effects on the serum concentration of adiponectin and orexin hormones, as well as body weight changes in adult female rats. Method: In this experimental study, 32 adult male Wistar rats were divided into four equal groups of eight rats: a control group, slim quick group (200 mg/kg), fat-stop group (200 mg/kg), and the group received slim quick (200 mg/kg) and fat-stop (200 mg/kg) simultaneously. The drugs were administered by oral gavage to animals. Twenty-nine days after the start of the experiment and after weighing the animals, cardiac puncture was performed and the serum concentration of adiponectin and orexin hormones were measured. The results were analyzed using ANOVA and Duncan test. The significance level was set at p≤0.05. Results: The results showed that there was a significant decrease in serum level of orexin hormone in both groups received slim quick and fat-stop compared to the control group; however, the serum level of adiponectin hormone did not show a significant change compared to the control group. In addition, the serum level of adiponectin hormone revealed a significant increase in the group received slim quick and fat-stop simultaneously and the serum level of orexin hormone was significantly decreased compared to the control group. Conclusion: According to the results, simultaneous administration of slim quick and fat-stop reduces body weight by increasing the serum level of adiponectin hormone and decreasing serum orexin level.
