Due to constant heavy loads and the need to provide a large volume of muscles with microelements, the athlete's body needs a special approach to nutrition. You can fill the deficiency of vitamins, minerals, and amino acids with the help of nutraceutical preparations. Citrulline malate is an interchangeable amino acid L-citrulline linked to an organic salt molecule (malate). The supplement is used in sports nutrition for powerlifters and bodybuilders to accelerate the growth of muscle mass and increase its functionality. The purpose of this study was a scientific substantiation and analysis of the effectiveness of the use of citrulline malate to increase the adaptive potential and physical performance of powerlifters at the preparatory stage of the annual cycle. A randomized study of 64 powerlifters was carried out. Athletes of the first group (control, n=32) trained as usual, enriching their diet with protein supplements and multivitamin complexes. Athletes of the second group (experienced, n=32) additionally received citrulline malate at a dose of 4 g 2 times a day for one month. Analysis of physical performance according to ergospirometry showed a more pronounced increase in physical performance in athletes of the experimental group.