Aims and Background: CABG surgery is the treatment of choice in many cardiovascular diseases. There are various factors that can disrupt patient’s sleep quality before and after CABG surgery. This study was conducted with the aim of evaluating the Effect of family centered care on sleep quality of post-CABG patients. Methods: This was a clinical trial that conduced in Alzahra cardiovascular hospital, Shiraz, Iran. 100 patients and one of their family member participated in this study. Participants were selected based on convenience sampling method and allocated to intervention or control group using table of random numbers. For the intervention group, family-centered care including three educative-supportive sessions and one month follow up was performed. The control group received routine cares. Sleep quality of patients was evaluated using Pittsburgh sleep quality index before, immediately after and one month after intervention. Data were analyzed with SPSS software using descriptive and analytical (chi-square, independent T-test) statistics. Results: Before interventions, the mean score of sleep quality in the control group was 7/94±1/82 and in the intervention group was 8/06±1/77. These two groups had not significance difference in this regard. Immediately after interventions, the mean score of sleep quality of patients in the control group was 7/86±1/83 and in the intervention group was 6/28±1/55. One month after interventions, the mean score of sleep quality the mean score of sleep quality of patients in the control group was 7/82±1/83 and in the intervention group was 5/82±1/53. The two study groups had significance difference regarding the mean score of sleep quality immediately and one month after interventions (P<0.001). Conclusion: The results of the present study showed that family-centered care effective in improving sleep quality of patients. This model can be used for improving quality of cares after CABG surgery.