Aims: This study evaluated the color changes of heat-cured denture-base acrylic resins and nylon-based dentures subsequent to storage in four different beverages. Methods: Twenty specimens were prepared for each denture base material and stored in distilled water for 24 hours at 37°C in a dark environment. During that time (T0), the color parameters of all the specimens were determined using a spectrophotometer. Each material was immersed in coffee, tea, Cola, and saliva (control). After 7 days (T1) and 30 days (T2) of immersion, the color of each specimen was measured again. The CIE (Commission International de L’Eclairage) L*a*b* was compared using two-way ANOVA and Bonferroni test at 0.95. Results: In ΔET0T1 and ΔET0T2, significant color changes were detected in both materials in coffee (P<0.05). Tea and Cola were the second most stain-inducing beverages for both materials. Nylone xhibited more color changes in coffee,tea,and Cola compared to PMMA (P<0.05). In ΔET1T2, there was no significant color change. Conclusion: The color changes induced at all the intervals were perceived by the Human eye (ΔE>1); however, they were in a clinically acceptable range (ΔE<3.3) except for those in coffee.