COVID-19 has taken the world by storm and is now posing as a massive burden on the healthcare services of the world. Another long-standing global epidemic is Diabetes mellitus and Diabetics who get infected with COVID-19 have been seen to have worse outcomes and a high non-survival rate. The global focus is to control the pandemic for which diabetes has proved to be a vulnerable group. The present review aimed to assemble the information about Diabetes mellitus and COVID-19 mainly focusing on the interrelation of pandemics of the past and Diabetes mellitus, possible pathophysiological mechanisms governing COVID-19 in diabetics, the effect of COVID-19 infection on underlying Diabetes mellitus, morbidity, and mortality in diabetic COVID-19 patients and finally the management of Diabetes mellitus in the current pandemic.it is concluded that this COVID-19 pandemic is still lurking and it is of great importance to highlight the fact that a high percentage of the population of the world is affected by various comorbidities like diabetes mellitus, hypertension, COPD, obesity, etc which makes a subset of the population more vulnerable. This vulnerable population is at increased risk for a poor outcome if affected by COVID-19. Hence, we as a society should prioritize this population at risk to avoid adding additional burden to the already overburdened health care system in the present COVID-19 scenario.