Introduction: heat shock proteins (HSPs) refer to intracellular proteins expressed in stress conditions in cell. In normal pregnancy, the level of HSP70 is reduced and an increase in the level of these proteins is associated with several complications of pregnancy. The role of HSP70 in normal and pathologic pregnancies is not well known. This research was conducted to evaluate the relationship between the level of type 70 heat shock protein in mothers with preeclampsia and complications caused by it. Methodology: This cohort study was conducted on 80 patients with preeclampsia in Alavi Hospital in Ardabil in 2017. These subjects were followed up during the study until the end of pregnancy. HSP70 level was measured in serum samples of patients using ELISA method. The collected data were analyzed by SPSS19 software and statistical tests. P -value less than 0.05 was considered significant.Results: In this study, the mean total of gestational age in patients was 33.99 ± 3.53 (32.30 ± 2.88 in the complicated group and 36.06 ± 3.17 in the uncomplicated group), and the difference between the two groups was statistically significant. In this study, 6.3% (n=5) of the patients had HELLP syndrome, 20% (n=16) had intrauterine growth retardation complication, 28 % (n=23) had preterm delivery and 45% (n=36) had no complication. The serum level of HSP70 was 22.69 ± 11.72 in the complicated group and 14.77 ± 3.32 in the uncomplicated group. There was a statistically significant difference between the two groups in terms of serum level of HSP70.Conclusion: Serum level of HSP70 was higher in preeclampsia patients than that in people with normal pregnancy. HSP70 can not only be a marker for these conditions, but also can play an important role in the preeclampsia pathogenesis.
