Background: Constipation is one of the most common medical complications of acute stroke and new onset constipation is associated with poor stroke outcomes. Purpose: The present study designated to investigate and compare new onset constipation response to Lactulose, Bisacodyl treatment in acute stroke patients. Methods: This is an interventional study of 45 patients admitted with acute stroke. Patients were examined by the defecation in second day and constipated patients were treated by lactulose or Bisacodyl randomly. Severity of stroke was assessed by means of NIHSS. Finally, response to treatment in both lactulose and Bisacodyl treated groups and correlation between stroke severity and response to treatment was measured. Results: Our finding showed that average response to treatment in Bisacodyl group was weaker than lactulose group. Nonetheless, there was positive significant correlation between severity of stroke and response to treatment. Other correlations were insignificant. Conclusions: This study showed that in acute stroke patients with acute constipation, Bisacodyl prescription might be associated with better neurologic outcome.
