Cervical cancer is the second most common cancer among women worldwide. It typically has a long pre-invasive state. Therefore, cervical cancer screening, potentially could prevent the occurrence of invasive cervical carcinoma through detection and treatment of pre- malignant disease. Material and Methods: This study was concluded at Zahedan (Iran), in 2015 to 2016.Speculum examination was carried out in 100 women. All patients were screened by Pap smear and visual inspection with acetic acid 3%-5 % (VIA). Positive cases by both screening methods were subjected to colposcopy and biopsy. Results: 76 Out of 100 patients, were negative with both screening techniqes.18 patients were positive with visual inspection with acetic acid 3%-5 % (VIA). While Pap smear was positive in 12 subjects and 6 subjects were positive with both tests. Woman divided to age groups (<30 year, 30-50year and >50 year). Overall, the sensitivity of visual inspection with acetic acid 3%-5 % (VIA) and Pap smear were 94.11% and 41.17% respectively. Corresponding specificities were 97.59%and 93.97% for VIA and PAP smear respectively, positive predictive value (PPV) for visual inspection with acetic acid 3%-5%(VIA) 88.88%versus 58.32% for Pap smear, and negative predictive value (NPV) for visual inspection with acetic acid 3%-5% (VIA) was 98.78% versus 88.63% for pap smear. The accuracy of visual inspection with acetic acid 3%-5 % (VIA) was 97% compared to 85% of Pap smear. Conclusion: These results indicate that visual inspection with acetic acid 3%-5 %( VIA) is sensitive and specific in comparison with Pap smear. It could be valuable in detection of precancerous lesions especially in patients under 30 years old.
