Introduction: Stroke (brain attack) is a sudden disruption of brain function that occurs as a result of vascular events. There are many risk factors in relation with stroke, some of which are unavoidable, such as age and sex, but some of them, such as high blood pressure, diabetes, hyperlipidemia, cigarettes and alcohol can be prevented or are treatable. The role of parameters such as copper and zinc in the pathogenesis of this disease is unknown. This study was carried out aimed to compare the concentration of copper and zinc in patients with ischemic noncardioembolic stroke with non-stroke patients. Materials and Methods: Our case-control study was carried out on 61 patients with noncardioembolic ischemic stroke and 61 healthy individuals referred to Kashan Health Center. Serum levels of copper, zinc, ceruloplasmin and homocysteine were measured in peripheral blood samples and urinary copper levels of all participants were measured. Finally, the data were collected and analyzed using statistical tests. Results: According to our findings, serum copper levels in patients (109.4 μg / dl) were significantly higher than normal subjects (97.35 μg / dl). (P = 0.02) Also, the copper urine level in patients (7.02 μg / dl) was significantly higher than healthy subjects (4.0 μg / dl). (P = 0.002) Serum zinc levels in patients (dl) were higher than normal subjects, but no significant difference was observed serum zinc level between the two groups (P = 0.162). Conclusion: Our results suggest that evaluation of serum copper level in noncardioembolic ischemic stroke patients may be useful for the prognosis and diagnosis of stroke. In this regard, it should be noted that more studies are needed to clarify the role of copper and zinc in patients with acute ischemic stroke.
