Background and objectives: This study was comparison the effects of Cotrimoxazole and Clindamycin on cellulitis with wound accompanied by purulent drainage or subcutaneous abscess in patients referred to Labafinejad Hospital during 2016_2017. Materials and Methods: 63 patients who had cellulitis with wound accompanied by purulent drainage or subcutaneous abscess were randomly divided into two groups. The first group was divided into two subgroups of inpatient and outpatient, oral clindamycin tablets were administered to outpatient subgroup and intravenous clindamycin was prescribed to inpatient subgroup. The second group was also divided into two subgroups of inpatient and outpatient. The outpatient subgroup received oral cortrimoxazole tablets and cotrimoxazole ampoules were administered intravenously to inpatient subgroup. Results: Patients were observed in two groups 1 and 2, in the first group 41.1% responded to treatment with intravenous clindamycin, in the second one 53.3% responded to treatment with intravenous cotrimoxazole, which did not indicate significant difference with the statistical calculation. Outpatients were evaluated in two groups 3 and 4, the first group responded 40% to oral clindamycin therapy, while the second group responded to treatment with oral cotrimoxazole 62.5%, which was not statistically significant difference. Conclusion: It seems that according to the results of this study, which, of course, cannot be generalized to the whole society, Despite the increasing prevalence of clindamycin resistance in methicillin resistant Staphylococcus aureus strains, none of these two drugs have not priority in treatment cellulitis with purulent drainage or subcutaneous abscess.
