Introduction: Among all hypertensive disorders, preeclampsia is a multisystem disorder with death in the fetus and mothers.in the study the level of plasma NO, TXA2, PGE2 and PGI2(as vasodilator and Vascular contraction) was compared between normal and preeclampsia pregnant women. Material and Methods: 40 preeclampsia and 40 healthy pregnant women were selected. The Nitrite and Nitrate (the stable product of NO) were measured by Griees reaction. The stable metabolits of thromboxane A2 (thromboxane TXB2), PGI2 (6-keto- prostaglandin Fla) and PGE2 were measured by revers - phase HPLC. Statistical analysis was performed using T-test and SPSS software. Results: the level of NO in the plasma of preeclampsia group was 36.22 ±5.4 µmol/l as compared to normal group (56.72±11.3) µ mole/l and PGI2, PGE2 and TXA2 in the palsma of preeclampsic women were 22.35±14.40, 92.57±46.18 , 2082.25±694 ng/ml respectively. meanwhile the level of them for control (normal) group were 118.07 ± 39.81(P<0.001), 240.92 ± 122.87(P<0.001) and 450.22 + 330.93(P<0.001), respectively, The ratio of TXA2/PGI2, used to express relative vasoconstriction vs vasodilation effect, was 83% higher in preeclampsia women to normal pregnant women (P<0.001). Conclusion: this study showed the significant reduction of NO, PGI2 a ,PGE2 and an increase in TXB2 in preeclampsia as compared to normal pregnant women, which suggests the role of above compounds in the pathogenesis of preeclampsia.Thus the measurements of these compounds Could be useful in diagnosis of early- preeclampsia and control of these factors for prevention of side effects of preeclampsia.
