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2021 Volume 12 Issue 1

Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats


Patonah Hasimun, Yani Mulyani, Hasballah Zakaria, Adinda Rizkia Setiawan
Abstract

Centella asiatica (CA) has been reported to have a protective effect on cardiovascular disease and cardiovascular disease-related conditions. Frontal QRS-T angle is a non-invasive biomarker that can predict cardiovascular mortality and morbidity in all causes of death. This study aimed to establish the protective effect of CA in animal models of metabolic disorders and its effect on the risk of cardiac ischemia by measuring the wide frontal QRS-T angle in animal models induced by high-fructose and high-fat diets. The study was carried out on thirty male Wistar rats distributed in 6 groups (n=5): groups 1 and 2 received (distilled water), group 3 received captopril 2.5 mg/kg, group 4-6 received 50, 100, 200 mg/kg of CA leaf extract, respectively for 14 days. All groups except the normal group received a 40% high-fat diet and 25% fructose in drinking water for 28days. Test drugs begin to be administered on days 15-28. CA leaf extract showed an antihypertensive effect and reduced body weight and triglyceride level, as well as the risk of cardiac ischemia, which was significantly different in comparison to the control group (p <0.05). It was concluded that CA has an impact on reducing the risk of mortality and morbidity due to cardiovascular events in metabolic disorder.


How to cite this article
Vancouver
Hasimun P, Mulyani Y, Zakaria H, Setiawan A R. Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats. J Biochem Technol. 2021;12(1):1-5. https://doi.org/10.51847/GzeDdExlEH
APA
Hasimun, P., Mulyani, Y., Zakaria, H., & Setiawan, A. R. (2021). Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats. Journal Of Biochemical Technology, 12(1),1-5. https://doi.org/10.51847/GzeDdExlEH
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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative