A crucial cell signaling molecule, zinc is a metal ion. Zinc is an insulin mimic, highlighting this by stimulating cellular pathways that control cellular homeostasis and physiological reactions. Numerous disease states, including cancer, obesity, cardiovascular disease, and diabetes. This study examined the effects of oral administration of ZnO NPs at various concentrations of 20, 40, 60, and 80 mg/kg/rat/day on groups of obese rats fed a high-fat diet. Rat groups that were obese had their lipid profiles, serum glucose levels, liver functions, and antioxidant enzymes assessed. These results were compared to healthy rats in the negative group. Biological investigation observed that in the different rats' groups taken orally ZnO NPs, the lipid profile analysis and glucose of serum were significantly decreased in the obese rat groups and nearly control negative. Meanwhile, high-density lipoprotein cholesterol was significantly increased, and low-density lipoprotein cholesterol was significantly decreased. The results from liver functions showed that in the groups that were given taken orally at 80.0 mg/kg rat/ day from ZnO NPs and fed high-fat, the ALT, AST, and ALK were significantly decreased by 27.84, 9.97, and 38.0 mg/dl, respectively. The results from antioxidant enzymes such as GSH, SOD, and CAT as well as MDA from the obesity rats group confirmed the above results. The current study recommends adding ZnO-NPs to the food of obese rats to improve the state of their liver function, lipid profile, and antioxidant enzymes as well as prevent further weight gain. This amount of ZnO-NPs, specifically 80 mg/kg, is suggested.
