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2019 Volume 10 Issue 2

Biocatalytic Preparative Methods of Asymmetric Alcohols using garlic (Allium ‎sativum)‎


Bilal Khaled, Lakhdar Sekhri, MajdaMokhtari, Mohammed Said Nedjimi, Tabchouche Ahmed, ‎ Touhami Benhachem, Fatah Benmoussa
Abstract

In this study,a mild, environmentally friendly method was reported for reduction of carbonyl compounds such as 4'-bromoacetophenone 1a and 4'-iodoacetophenone 2aby the biocatalyticcut ripe fresh garlic(Allium sativum)at room temperature in an aqueous medium, to the corresponding chiral alcohols 1b and 2b.The results showed that garlic can be used as biochemical catalysts to contribute to the preparation of many pharmaceutical alcohols. This biochemical catalyst attracted much attention because of the low cost, high efficiency and special selectivity for its environmental friendliness and its contribution to certain recommended green chemistry principles. The prochiral ketones: 4'-bromoacetophenone 1a and 4'-iodoacetophenone 2amixed with the biocatalyticcut of ripe fresh garlic(Allium sativum)were chosen as typical ketones and the yield and optical purity were (65-75%) and (86-92%), respectively. Mild reaction condition, simple operation, and easy availability of freshvegetable revealed this protocol as an attractive and alternative eco-friendly option for a general reduction of all types of carbonyl compounds‎‎‎‎.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

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FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative