In this study,a mild, environmentally friendly method was reported for reduction of carbonyl compounds such as 4'-bromoacetophenone 1a and 4'-iodoacetophenone 2aby the biocatalyticcut ripe fresh garlic(Allium sativum)at room temperature in an aqueous medium, to the corresponding chiral alcohols 1b and 2b.The results showed that garlic can be used as biochemical catalysts to contribute to the preparation of many pharmaceutical alcohols. This biochemical catalyst attracted much attention because of the low cost, high efficiency and special selectivity for its environmental friendliness and its contribution to certain recommended green chemistry principles. The prochiral ketones: 4'-bromoacetophenone 1a and 4'-iodoacetophenone 2amixed with the biocatalyticcut of ripe fresh garlic(Allium sativum)were chosen as typical ketones and the yield and optical purity were (65-75%) and (86-92%), respectively. Mild reaction condition, simple operation, and easy availability of freshvegetable revealed this protocol as an attractive and alternative eco-friendly option for a general reduction of all types of carbonyl compounds.
