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2019 Volume 10 Issue 3

Asymmetric Bioreductionof Ketones with a Pumpkin (cucurbita)‎


Bilal Khaled, LakhdarSekhri, MessaoudaGuemmouda, Mohammed Said Nedjimi, Touhami‎ Benhachem, Fatah Benmoussa
Abstract

In this study, a general, efficient, and simple methodology for biocatalytic reduction of carbonyl ‎compounds such as acetophenone 1a and 4-chloroacetophenone 2a using freshly cut ripen fruit of fresh ‎pumpkin in the aqueous medium at room temperature was reported. The prochiral ketones can be ‎reduced to chiral secondary alcohols in a generalized way. The obtained results indicated that the ‎pumpkin fruits could be used as biochemical catalysts to contribute to the preparation of many ‎pharmaceutical alcohols. This biochemical catalyst attracted much attention because of the low cost, ‎high efficiency, and special selectivity for its environmental friendliness and its contribution to certain ‎recommended green chemistry principles. ‎

In this research, our aim was to contribute to this area by using biochemical catalysts with plant ‎sources such as the pumpkin fruits in different states (fresh, juice). The prochiral ketones: ‎acetophenone and 4-chloroacetophenone were chosen as typical ketones and the yield and optical ‎purity were 77-88% and 50-96%, respectively. Mild reaction condition, simple operation, and easy ‎availability of fresh pumpkin fruit revealed this protocol as an attractive and alternative eco-friendly ‎option for a general reduction of all types of carbonyl compounds‎‎‎‎.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative