Background and objectives: On of the most important complaints of a large number of pregnant women is nausea and vomiting which can affect their own health and their growing fetuses. Given the few number of studies on the causes of nausea and vomiting in pregnancy, in particular the role of psychological factors in creating it, this study is aimed to determine the association between nausea and vomiting of pregnancy and psychological factors in pregnant women. Materials & Methods: The present study is a descriptive-correlational study. Participants in the study were 335 healthy single fetus pregnant women with a gestational age of 6-16 weeks referred to various health centers in city of Abadan who had inclusion criteria. Samples were randomly selected. All participants completed the Rhodes Index of Nausea and Vomiting Form 2 (INV- 2), Spielberger's State-Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale (EPDS). Ultimately, the data were analyzed by means of SPSS software. Results: The results indicated a direct and significant relationship between the incidence of nausea and vomiting in pregnancy with the anxiety and depression in pregnant women. Also 62.1 % of participants had nausea and vomiting. Conclusion: Since anxiety and depression in pregnancy can hurt the mother and fetus’ health and lead to nausea and vomiting in pregnancy, it is suggested that, beside other examinations performed during pregnancy, psychological problems of the pregnant mother is also detected, referred and treated.