The study was to assessment of diabetes mellitus related complications in inpatients at a tertiary care hospital, Baptist hospital, Bangalore. A prospective descriptive study was conducted over 6 months, after taking ethical committee approval. 150 In patients diagnosed with diabetes will be enrolled to the study. Demographic data, detailed medical history, medications for diabetes mellitus, concomitant medications for co morbid diseases, Pharmacoeconomics, questions regarding lifestyle, dietary pattern, and exercise program with laboratory investigations were recorded in the study preform. Also reporting any drug interactions, adverse drug reactions or contraindication related to diabetes medications. Diabetes complication includes all micro vascular and macro vascular complications. Diagnosis of diabetic complications was done by physician and complications and laboratory results were taken from patient cards. The Micromedex, Medscape and references books will be used as tools to review the prescription and case charts. Majority of the patients were male (64.4%). The average age of the study population was 60.34±12.04 years. Most of the patients had a diabetes history of more than 10 years and HbA1c > 8%. The average QoL score was 65.47±15.07. Majority of the diabetic patients had the QoL score between 70 and 50. Patients without complication had a better QoL. As the number of complications increased, there was a decrease in the QoL. The presence of comorbidity also decreased the QoL. There was a statistically significant correlation with various parameters such as age, duration of diabetes history, HbA1c, number of complications and type of complication verses QoL of diabetic patients (p<0.05). The overall QoL in diabetic patients is reduced. Thus, proper management and strict glycemic control is necessary to prevent progression and occurrence of complications to maintain a better QoL in diabetes patients. It was observed that tablet metformin and Inj. Actrapid (Insulin) is most frequent medication that prescribed among diabetic patients without complications.