Prescription audit is one of the important component of clinical pharmacy, where clinical pharmacist plays important role in optimization of medication use, minimizing number of medication-related problems and improving medication therapy. The main objective of present study is to find out the loose links between medication prescribing and its utilization in pediatric department especially with drugs belongs to Antiepileptic medication category. This prospective observational study carried out for a period of 6 months in the Department of Pharmacy practice, Karnataka College of pharmacy, Bangalore Baptist Hospital, Bangalore. The study was conducted on 100 patient receiving Antiepileptic Medication. The study showed that the maximum number of patient receiving antiepileptic medication belongs to age group of 2 to 6 years, while comparing the prevalence of ADR Levetiracetam, phenytoin and clobazam was identified which are associated with ADR, the highly prescribed drug was Valproic acid and carbamazepine. The ADRs documented was Loss of appetite, vomiting, anemia and Steven-Johnson syndrome. Evaluation of prescription was performed as which is major factor in drug related ADRs. In the discussion part various methods of improvement in prevention of ADRs due to prescription error has been suggested which can improve the drug utilization and precaution. An economic study is done in the end to put a light on the cost effective treatment therapy which might improve patient adherence.