Objective: The present study is aimed to evaluate to Antiplatelet Activity of Aspirin in the Prevention of Cardiovascular Disease. Methodology: Cardiovascular disease (CVD) is a group of general category diseases that affects the heart and the circulatory system. CVD is caused by disorders of the heart, blood vessels that includes coronary heart diseases (CHD), congestive heart failure (CHF), stroke, Hypertension (HTN), peripheral artery disease (PAD) and rheumatic heart disease (RHD). The leading cause of death in India is CVD, India will notice a large number of people between 35 and 64 years die of CVD over the next 30 years as well as an increasing level of morbidity due to CVD. Drug therapy is a pillar of CVD prevention in such individuals and its cost/effectiveness ratio seems particularly favorable. Low-dose aspirin is a well-known, effective, cheap, and easy to use preventive drug. Drugs in a tertiary care hospital is a retrospective observational cross-sectional study, Patients who were satisfying the inclusion criteria was enrolled into the study conducted for the period of 6 months. Data collection form and other relevant source from Medical Record department are used as source of data and materials. Result: In our study 150 cases were examined in tertiary care hospital who were prescribed with Aspirin in cardiology department among that 108(72 %) were male and 42 (28%) were female. Accompanying major age group having CAD is 60- 70 years i.e. 41(27.33 %) and 50-60 yrs. i.e. 39(26%). Regarding co-morbidity where aspirin was used, 34.67% of patients had CAD with HTN and 26.67% patients had CAD alone. Aspirin was mostly indicated for ischemia 50(33.33%) and Myocardial infarction 48(32%).In tertiary care hospital 150 mg of aspirin was highly used 50.67% followed by 75 mg 44%. Conclusion: Since 58.67% of prescription consist of aspirin in combination with other Antiplatelet drugs when compared with aspirin alone (41.33%), combination drug seems to be more effective in CAD patients.
