Naturally-occurring antioxidants are of particular interest because of their ability to trap free radicals and prevent destructive processes caused by oxidative stress. The purpose of this study was to investigate the antioxidant activity of three herbal extracts from the root of pelargonium purifying (Pelargonіum sіdoіdes), ivy leaves (Hedera helix L., Hedera caucasigena Pojark) and oregano (Origanum vulgare L.) with different combinations of their ratios. These plants were chosen based on their wide use by traditional medicine healers to treat various diseases. Extraction conditions were selected for each plant separately, and ethanol was used as an extractant. Thick extracts of the studied plants were dried to obtain dry extracts with a moisture content not exceeding 1%. A definition of antioxidant activity (AA) of the studied multicomponent drug solutions was performed in vitro using DFPH (2,2-diphenyl-1-picrylhydrazyl) free-radical method. The results obtained show high AA of solution #7 in which the ratio of active pharmaceutical ingredients was almost the same (tannins: hederocoside: thymol and carvacrol = 1: 1: 1.25). Solutions #3 and #4, which contained 1.4 mg of tannins, 1 mg of hederocosids, and 3 mg of thymol and carvacrol in 100 ml of ethanol, also showed high AA. Multicomponent drugs #5 and 6 were the least effective. Thus, the antioxidant activity of multicomponent drugs based on extracts from purifying pelargonium root, common ivy leaf, and common oregano herb was investigated. The results of the research indicate the promising use of multicomponent drugs #7, 3, and 4 as antioxidant remedies.