Antibacterial activity of leaf extract of Delonix elata and molecular docking studies of Luteolin

 In vitro antibacterial activity of leaf extract of Delonix elata was screened against both gram negative and gram positive bacteria. The methanol extract of leaf showed significant antibacterial activity against Klebsiella pneumonia (18.40 ± 0.80) and Bacillus subtilis (17.60 ± 0.55) with minimal inhibitory concentration of 1mg ml-1 and exhibited less bactericidal activity against P. vulgaris (9.83±0.31).  In silico docking  of Luteolin, a bioactive  compound  from leaf extract of D. elata  with  a  key  enzyme  of bacterial Glucosamine-6-phosphate synthase, showed significant inhibition with minimum docking energy -10.12 kJ mol-1, binding energy -10.07 kJ mol-1 and inhibition constant 4.14e-008. The molecular docking study was comparatively evaluated with the standard drug ciprofloxacin with an inhibition constant of was 4.2e-007. This investigation supports the medicinal claim of             D. elata.