Background: Cancer pains are among high-severity pains that require multidimensional control and management, because such pains cause an urgent need for opioids that have undesirable side effects for patients. Objective: The present study aimed to investigate the analgesic effects of ozone on celiac plexus neurolysis (CPN), reduced need for opioids, and quality of life in patients with pancreatic cancer. Methodology: The present research was a cross-sectional descriptive study. The sample size was determined to be 40 and the participants were selected based on convenience sampling method. In the mediosefal approach, the anterior edge of L1 vertebra and then posterior aorta were caused to pass the aorta using the loss liquid method and the desired site was determined at the anterior aorta and posterior perineum by injecting a radiocontrast agent under fluoroscopic guidance. Then, ozone was administered to the desired site using 0.05% Marcaine (Bupivacaine) plus 40mg of Depo-Medrol (methylprednisolone). After confirmation of analgesia by the patient, CPN was done using 55 mg/l of ozone. The data were statistically analyzed using Pearson correlation coefficient, analysis of variance, chi-square test, Fisher’s exact test, and logistic regression analysis in SPSS-19 at 0.05 level of significance. Results: The severity of pain significantly reduced over time in patients who received ozone (p<0.001). However, such a significant reduction was not observed in patients who were treated with alcohol (p=0.029). The results also showed that improvement in the quality of life over time was significantly higher in patients who received ozone (p<0.004) compared to those treated with alcohol (p=0.019). In addition, there was a significant difference in the opioid dosage administered to patients before and after the celiac plexus blockage (p<0.001). Conclusion: As a new medical treatment for celiac plexus blockage in patients with pancreatic cancer, ozone therapy was shown effective in reducing severity of pain and need for opioids and other analgesics and improving quality of life.
