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2020 Volume 11 Issue 4

An Overview on Diagnosis and Management of Cardiac Defects in Down Syndrome in Pediatric Age


Hanan A. Alrashidi, Emtenan K. Alharbi, Rehab M. Aldossari, Alghanmi M. Wasal A, Nawaf K. Almuzaini, Almunthir A. Alrehaili, Hatim O. Alhazmi, Mazin T. Alshammari, Abdulrahman M. S. Aldawsari, Mohammed A. Althobaiti, Sana H. AL-huwaijy
Abstract

Background: Down syndrome (DS) is one of the commonest disorders associated with chromosomal abnormality with a huge medical and social cost. DS is associated with several phenotypes including congenital heart defects, the point of our discussion. DS individuals are affected by these phenotypes to a variable extent thus understanding the cause of this variation is a key challenge. In this review, we will talk about the common congenital cardiac disease running in patients with down syndrome. Objectives: We aimed to review the literature on cardiac defects associated with Down’s syndrome, along with the etiology, clinical features, evaluation, diagnosis, and management of these types. Methodology: PubMed database was used for articles selection, papers were obtained and reviewed. Conclusion: Down syndrome is associated with a variety of congenital cardiac defects. Proper knowledge of these defects with the management approach is essential. Due to advancements in technology, prenatal diagnosis is possible. Almost all these conditions are cured by surgical repair and carry an excellent prognosis.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative