Background: Adverse drug reactions, or ADRs. which are officially described as: "A response to a drug which is noxious and unintended, and which occurs at doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological function. ADRs also might be results of polypharmacy, Pathogenesis, paradoxical reaction and other serious adverse events. This study aimed to recognize adverse drug reaction in the in-patient department and hence to find the predisposing factors associated with ADR.Result: Throughout the 6 months’ study period, 70 ADR's were confirmed and reported in 69 patients. There were 3000 patient admission (which is taken for this study) at the hospital and the overall incidence of ADR's during hospitalization in this patient group was 2.33%. Mean age of the patient were 48.93 year. Among the study population 19(27.14%) were geriatric patients ,45(64.28%) were adults and 6(8.57%) were children and teenagers.Conclusion: provides the evidence that the incidence of ADR is relatively common in older patients and 50% of these cases could potentially be prevented if certain measures are taken. Additionally, there is also data confirming that the rate of ADR is increased in older patients although the rate remains relatively constant 35 patients gets much older i.e. above 80 years. The recognition of ADR is quite challenging in the patients, the prospective nature of identifying cases and classification of suspected events by independent reviewers increases the reliability of the Endings. Further effort to develop and design a preventative strategy should be imbued as there is a constant need to provide better health care especially in the Population.