Hematological reference values are very important for diagnosing and interpreting the results and decision-making to assess the hematological parameters among children diagnosed with Down Syndrome in Khartoum State-Sudan. A total of 60 subjects were enrolled in the study. Of them, 30 individuals were patients with Down Syndrome, and 30 apparently healthy individuals were considered control throughout the period from (September 2020 to December 2020). A total of 2.5 ml of venous blood were collected in EDTA containers and investigated using SysmexKX-21N analyzer; the data were analyzed using SPSS – Independent T-test at a 5% level of significance. study revealed that the mean of MCHC and Platelets count for Down Syndrome patients were significantly (P value≤0.00) decreased (32.10±2.42, and 183.27±99.10). Moreover, no significant change in RBCs count, HB, MCV, HCT, MCH, and WBCs values for both groups. The study concluded that Down Syndrome has an obvious effect on some hematological profiles by decreasing Platelets and MCHC. Still, there is no effect on RBCs TWBCs and other RBCs indices.
