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2012 Volume 4 Issue 1

A review on lovastatin and its production


Abstract
Natural statin like lovastatin which is mainly produced byAspergillus terreus strains is an inhibitor of HMG-CoA reductase,an enzyme involved in the biosynthetic pathway of cholesterol. Themechanism involved in controlling plasma cholesterol levels isthe reversible competitive inhibition of HMG-CoA which binds tothe HMG-CoA reductase due to the structural homology betweenthe β-hydroxyacid form of the statins and the HMG-CoAintermediate formed. Mainly Lovastatin are produced industrially byliquid submerged fermentation which decreases the production costcompared to costs of chemical synthesis. Lovastatin application partis in various field like management of hypercholesterolaemia,cholesterol lowering actions, reduce the prevalence of Alzheimer’sand renal disease etc. This review deals with the structure,properties, biosynthetic pathway, submerged fermentation,applications and side effects of lovastatin.

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal of Biochemical Technology provides a publication on all aspects of biochemistry, biotechnology & bioinformatics and applications in biology and medicine. Areas of high interest cover new advances in enzymatic and protein mechanisms; applied molecular genetics and biotechnology; computational biology, genomics and proteomics; metabolic & tissue engineering; medical, environmental, Pharmacy and pharmaceutical chemistry, food and agro-biotechnology.

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative