The Relationship Between Serum Zinc and Magnesium Levels and Depression in ‎Postmenopausal Women

Fatemeh Nazari , Khadijeh Hekmat‎‏*‏ , Mina Iravani , Mohammad Hosein Haghighizadeh , ‎Hatam Boostani


Background and Objective: Depression is the most common mental disorder in ‎different societies, and it is estimated to be the second most common disease followed ‎by cardiovascular disease by 2020. Zinc and magnesium may play a role in the ‎pathophysiology of depression. Therefore, the present study was designed to ‎investigate the relationship between serum zinc, magnesium, and depression in ‎postmenopausal women.‎ Materials and Methods: This was a case-control study of 68 depressed women ‎and 68 non-depressed women. At first, after completing the informed consent and ‎demographic questionnaire and the Beck Depression Inventory, the blood samples were ‎collected, centrifuged and frozen. Then, the zinc and magnesium levels were evaluated ‎by the flame atomic absorption technique. Data were analyzed using SPSS-Ver22, chi-square test, independent t-test, and logistic regression. P values < 0.05 was considered ‎significant.‎ Results: The mean serum zinc and magnesium levels were 88.26 ± 21.21 µg/dl,‎‏ ‏‎1. 82± ‎‎0/49 mg/dl in case group and 102.64 ± 24.41 µg/dl, 2.17 ± 0.57 mg/dl, in control group ‎respectively, which showed a significant difference between mean and standard ‎deviation of serum zinc and magnesium levels in both case and control groups. Based ‎on logistic regression analysis, the increase in serum zinc levels is associated with a ‎reduction in the depression risk [odds ratio: 1‎‏.‏‎027; CI 95%: 1‎‏.‏‎011 to 1‎‏.‏‎044]. Moreover, ‎the increase in serum magnesium levels is associated with a reduction in the ‎depression risk [odds ratio: 3/278; CI 95%: 1‎‏.‏‎62 to 6‎‏.‏‎602].‎ Conclusion: Based on the findings, serum zinc and magnesium levels in the case ‎group were lower than that of the control group. This valuable information can be used ‎in planning to prevent depression‎.