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2018 Volume 9 Issue 4

The Impact of Heavy Metals in Impairment of Spermatogenesis and Sperm Density in the Human

S. A. Habib, M. A. Elbakry, M. A. Sakran, E. A. Toson, R. A. El-Baz, Marwa E. Elafify

Spermatogenesis is the most important stage in male fertility. In the present study, many factors affecting spermatogenesis were evaluated in seminal plasma and homogenates of sperms from fertile and infertile males. The levels of some heavy metals, malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD) activity were measured in both seminal plasma and homogenate supernatant of sperm from fertile and infertile males. Two hundred and sixteen human semen samples were collected and divided into five groups: group I (GI) included 70 semen samples as the control, and four infertile groups (GII - GV) according to WHO criteria. The levels of Fe2+, Cd2+ and MDA in seminal plasma and sperm homogenate supernatant of infertile groups were highly and significantly increased compared to their levels in control. However, GSH level and SOD activity in seminal plasma and sperm homogenate supernatant of infertile men were highly and significantly decreased compared to the control. In conclusion, the levels of heavy metals and oxidative stress were associated with human male spermatogenesis dysfunction and might be useful tools in predicting sperm density.


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Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative