Preparation of Molecularly Imprinted Polymers Coupled with Magnetic Nanoparticles for the Selective Extraction of Propranolol from Aqueous Solution of Propranolol, Atenolol and Metoprolol

Mehdi Samizadeh , Mahmoud Ebrahimi and Mehdi Pordel

Abstract

In this work, highly selective molecularly imprinted polymers (MIPs) of propranolol on the internal surface of hollow fiber were prepared. The resulting MIP coated MNP were used as dispersive solid phase micro extraction (SPME) fiber coupled with HPLC-UV for the selective extraction and detection of propranolol. Encouraging result was obtained. Method was evaluated and enrichment factors, relative standard deviations and linearity ranged for propranolol 918.8, 2.9% and 25-3000 ng.ml-1 were obtained, respectively.

References

Balogh D, Tel-Vered R, Riskin M, Orbach R, Willner I. Electrified Au nanoparticle sponges with controlled hydrophilic/hydrophobic properties. ACS nano. 2010 Dec 9;5(1):299-306.

Bargmann-Leyder N, Sella C, Bauer D, Tambute A, Caude M. Supercritical fluid chromatographic separation of. beta -blockers on chyrosine-A: Investigation of the chiral recognition mechanism using molecular modeling. Analytical Chemistry. 1995 Mar 1;67(5):952-8.

Black SB, Stenhouse AM, Hansson RC. Solid-phase extraction and derivatisation methods for β-blockers in human post mortem whole blood, urine and equine urine. Journal of Chromatography B: Biomedical Sciences and Applications. 1996 Oct 11;685(1):67-80.

Cline-Love, L.J.; and Fett, J.J. (1991) ʻʻOptimization of Selectivity in MLC Procedures for the Determination of Drugs in Urine by Direct Injectionʼʼ J. Pharm. Biomed. Anal, 9: 323.

Egginger G, Lindner W, Brunner G, Stoschitzky K. Direct enantioselective determination of (R)-and (S)-propranolol in human plasma. Application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 1994 Dec 1;12(12):1537-45.

El-Saharty YS. Simultaneous high-performance liquid chromatographic assay of furosemide and propranolol HCL and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2003 Nov 24;33(4):699-709.

Elsayed MA, Barary M, Abdel-Salam M, Mohamed S. Spectrophotometric assay of certain cardiovascular drugs through charge transfer reactions. Analytical letters. 1989 Jun 1;22(7):1665-84.

Feely, J. (1994) ʻʻNew Drugs, third edʼʼ BMJ Publishing Group, London, p. 94.

Gai QQ, Qu F, Liu ZJ, Dai RJ, Zhang YK. Superparamagnetic lysozyme surface-imprinted polymer prepared by atom transfer radical polymerization and its application for protein separation. Journal of Chromatography A. 2010 Jul 30;1217(31):5035-42.

Geissler HE, Mutschler E. Quantitative thin-layer chromatography and its use in clinical pharmacology (author's transl). Arzneimittel-Forschung. 1978;28(11a):1964.

 Haripriya S, Ajitha P. Antimicrobial efficacy of silver nanoparticles of Aloe vera. J Adv Pharm Edu Res 2017;7(2):163-167.

Holthoff EL, Bright FV. Molecularly imprinted xerogels as platforms for sensing. Accounts of chemical research. 2007 Jun 29;40(9):756-67.

Li L, He X, Chen L, Zhang Y. Preparation of core‐shell magnetic molecularly imprinted polymer nanoparticles for recognition of bovine hemoglobin. Chemistry–An Asian Journal. 2009 Feb 2;4(2):286-93.

Lopez JA, Martınez V, Alonso RM, Jimenez RM. High-performance liquid chromatography with amperometric detection applied to the screening of 1, 4-dihydropyridines in human plasma. Journal of Chromatography A. 2000 Feb 18;870(1-2):105-14.

 Mahmoud,Z. Hassan, K.H. Abdul Sattar, O.D. & Kefah Ali,F. Low Temperature Novel Photosynthesis Method and Characterization of ZnO/CuO Nano composite. J Biochem Tech (2018) 9(3): 1-4.

Ma J, Yuan L, Ding M, Wang S, Ren F, Zhang J, Du S, Li F, Zhou X. The study of core–shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles. Biosensors and Bioelectronics. 2011 Jan 15;26(5):2791-5.

Mullett WM, Martin P, Pawliszyn J. In-tube molecularly imprinted polymer solid-phase microextraction for the selective determination of propranolol. Analytical chemistry. 2001 Jun 1;73(11):2383-9.

Paik P, Gedanken A, Mastai Y. Enantioselective separation using chiral mesoporous spherical silica prepared by templating of chiral block copolymers. ACS applied materials & interfaces. 2009 Aug 10;1(8):1834-42.

Pham-Huy C, Radenen B, Sahui-Gnassi A, Claude JR. High-performance liquid chromatographic determination of (S)-and (R)-propanolol in human plasma and urine with a chiral β-cyclodextrin bonded phase. Journal of Chromatography B: Biomedical Sciences and Applications. 1995 Mar 10;665(1):125-32.

Ruane RJ, Wilson ID. Ion-pair reversed-phase thin-layer chromatography of basic drugs using sulphonic acids. Journal of Chromatography A. 1988 Jan 1;441(2):355-60.

Sultan SM. Kinetic determination of propranolol in drug formulations. Analyst. 1988;113(1):149-52.

Walshe M, Kelly MT, Smyth MR. Comparison of two extraction methods for determination of propranolol and furosemide in human plasma by mixed-mode chromatography. Journal of pharmaceutical and biomedical analysis. 1996 Feb 1;14(4):475-81.

Wang S, Li Y, Wu X, Ding M, Yuan L, Wang R, Wen T, Zhang J, Chen L, Zhou X, Li F. Construction of uniformly sized pseudo template imprinted polymers coupled with HPLC–UV for the selective extraction and determination of trace estrogens in chicken tissue samples. Journal of hazardous materials. 2011 Feb 28;186(2-3):1513-9.

Wang X, Wang L, He X, Zhang Y, Chen L. A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition. Talanta. 2009 Apr 30;78(2):327-32.

Zelikman I, Hjertén S. Determination of total and free concentration of propranolol in human plasma by displacement electrophoresis in a two‐layer polyacrylamide gel using fluorimetric detection. Biomedical Chromatography. 1989 Jul;3(4):161-5.

Zhang Y, Li Y, Hu Y, Li G, Chen Y. Preparation of magnetic indole-3-acetic acid imprinted polymer beads with 4-vinylpyridine and β-cyclodextrin as binary monomer via microwave heating initiated polymerization and their application to trace analysis of auxins in plant tissues. Journal of Chromatography A. 2010 Nov 19;1217(47):7337-44.

Zhou WH, Lu CH, Guo XC, Chen FR, Yang HH, Wang XR. Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition. Journal of Materials Chemistry. 2010;20(5):880-3.



Download PDF