Objective: Preeclampsia (PE) is a common disorder in pregnancy. Corticotrophin-releasing hormone (CRH)ats through vasodilatory effects. The aim of this study is diagnosis of PE by molecular of circulating CRH and Ep mRNA of placental in maternal plasma. Material and methods: The study was performed in early pregnant women with PE (n= 28) and normal pregnant women (n=30) as control group, blood samples was taken from each mother. Total RNA was isolated from harvested plasma synthesized from RNA samples using reverse transcription kit (Gen net bio) by the instructions of the manufacturer. Results: The Results indicated that expression of CRH was significantly different amongwomen suffered from preeclamptic compare of healthy pregnant women. Conclusion: This study demonstrated that thosemRNA concentrations were increased in the plasma of PE patients compared with those of normalsubjects and suggest the opportunity to gain furtherinsight into pathological pregnancy through mRNA measurementsin maternal plasma.