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2010 Volume 2 Issue 3

Melatonin attenuates lipid peroxidation and enhances circulatory antioxidants during mammary carcinogenesis in rats


Abstract
The possible protective effect of Melatonin was investigated for its antioxidant and lipid peroxidation activity against 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female albino Wistar rats. Mammary tumor was developed to the animals by administering 5mg/kg body weight of DMBA orally at weekly intervals for one month. Intraperitoneal administration of melatonin 5mg/ml per animals for 15 days prior to the first oral administration of DMBA was continued for a month. After the experimental period, oxidative stress parameters were assessed in plasma of both control and experimental groups. A significant increase in lipid peroxidation levels were observed in cancer induced rats while the activities of enzymic and non-enzymic antioxidants were decreased in cancer-bearing animals when compared to control animals. Administration of melatonin remarkably reduced the lipid peroxidation activity and increased the antioxidants level in drug treated animals. This result suggests that melatonin shows antioxidant activity and play a protective role against 7, 12-dimethylbenz(a)anthracene induced breast cancer. The inhibitory effect of melatonin on tumor cells and its lack of side–effects, indicate that melatonin should be considered as an adjuvant drug in the treatment of neoplastic diseases.

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a double-blind peer reviewed International Journal published by the Deniz Publication on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative