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2012 Volume 3 Issue 4

Fermentation kinetics makeover in poly-ε-lysine biosynthesis by Streptomyces noursei NRRL 5126


Abstract
An unstructured model has been used to predict microbial growth based on glycerol consumption and poly-ε-lysine (ε-PL) biosynthesis by Streptomyces noursei NRRL 5126. The logistic and Luedeking-Piret equations have been proposed to describe the time course of ε-PL formation, substrate consumption and cell growth. The shake flask level data from kinetic studies was illustrated and compared with fermenter studies. In all cases, the model simulation matched well with the experimental observations, which made it possible to elucidate the fermentation characteristics of Streptomyces noursei during efficient ε-PL production from glycerol. Optimized oxygen supply into the fermenter shifted mixed growth associated biosynthesis of ε-PL from shake flask level to growth associated biosynthesis. 

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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative