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2015 Volume 6 Issue 1

Esterase’s properties in commonly used Indian spices for Alzheimer’s disease model


Abstract
Esterase family of Hydrolases such as Acetylcholinesterase (AchE),Butyrylcholinesterase (BchE) and Carboxyl esterase (CE) havebeen estimated in Alzheimer’s disease (AD) model, normal brain ofstriatum, frontal cortex, hippocampus and in liver. In AD a loss ofacetylcholine activity directly correlates with memory dysfunctiondue to the activation of acetylcholinesterase andbutyrylcholinesterase enzymes. Therefore the effective treatmentmethods include restoration of cholinergic function and elevation ofACh level through inhibiting AChE and BChE. Hence to inhibitthese enzymes four commonly used Indian kitchen spices viz.,Cuminum cyminum, Elettaria cardamomum, Cinnamomum verum,Syzygium aromaticum were selected because the extracts of thesespices contain cholinesterase inhibitory activity in vitro. Thesespices were extracted with cold and hot aqueous solution and theanti- cholinesterase potential was measured in vitro. Elettariacardamomum cold extract showed significant inhibition for AchE inall regions of brain for control and AD. Whereas Cinnamomumverum hot extract showed elevated activity for carboxyl esterasewhich is a neuroprotective factor. These findings suggest thatdietary supplementation of cardamom and cinnamon in moderateamounts may aid in prevention delay in onset of AD.

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative