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2019 Volume 10 Issue 4

Assessment of Hematological Parameters, Enzymes Activities, and Oxidative Stress ‎Markers in Salivary and Blood of Algerian Breast Cancer Patients Receiving ‎Chemotherapy


Derouiche Samir, Atoussi Naouel, Guediri Safa‎
Abstract

The objective of this study was to evaluate the variation and importance of certain hematological, enzymatic, and oxidative stress markers in women with breast cancer under chemotherapy treatment. Hematological parameters, enzymes’ activities, and oxidative stress status were estimated in cancer patients and the sensitivity and specificity of biomarkers (MDA, GSH, Catalase, and ORAC) in blood and saliva were compared between the patient and control groups using receiver operating characteristics (ROC) curve design. Results showed that the erythrocyte line (RBC, HGB, and HCT) significantly decreased (p <0.001, p <0.01, and p <0.05, respectively) and ALP, amylase, and transaminases activities were not significantly changed in breast cancer patients group compared to the control group and the reference values. The results showed that GSH levels in leukocytes, erythrocytes, and saliva, as well as ORAC in serum, were significantly increased in patients with breast cancer compared to healthy controls, whereas MDA level and catalase activity did not change significantly. On the other hand, there was not any significant correlation in GSH levels between erythrocyte, leukocyte, and saliva in patients and control groups. ROC analysis indicated that GSH and ORAC levels are better diagnostic tools than other oxidative markers, suggesting to be used as systematic markers for diagnosis and prognosis of breast cancer‎‎.


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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative