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2012 Volume 4 Issue 1

A review on lovastatin and its production


Abstract
Natural statin like lovastatin which is mainly produced byAspergillus terreus strains is an inhibitor of HMG-CoA reductase,an enzyme involved in the biosynthetic pathway of cholesterol. Themechanism involved in controlling plasma cholesterol levels isthe reversible competitive inhibition of HMG-CoA which binds tothe HMG-CoA reductase due to the structural homology betweenthe β-hydroxyacid form of the statins and the HMG-CoAintermediate formed. Mainly Lovastatin are produced industrially byliquid submerged fermentation which decreases the production costcompared to costs of chemical synthesis. Lovastatin application partis in various field like management of hypercholesterolaemia,cholesterol lowering actions, reduce the prevalence of Alzheimer’sand renal disease etc. This review deals with the structure,properties, biosynthetic pathway, submerged fermentation,applications and side effects of lovastatin.

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J BIOCHEM TECH
J BIOCHEM TECH
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative