Introduction: Spiritual intelligence as the basis of individual beliefs plays a fundamental role in various fields of human life, especially the provision and promotion of mental health. On the other hand, the role of happiness in mental health, physical health, and effective social participation is considered very important. This study was attempted to determine the relationship between spiritual intelligence and happiness among students of Bam University of Medical Sciences. Methods: In this descriptive-analytical study, 272 students from three different departments’ of Bam University of Medical Sciences (Health Department, Nursing and Midwifery Department, and Medicine Department) participated. To determine the sample size, the Cochran formula was used. For data collection, Spiritual Intelligence Self-Assessment Inventory and Oxford Happiness Questionnaire were used in the present study. The data were analyzed by using SPSS (version 23) and running Pearson correlation coefficient and independent t-test. Results: Having compared the relationship between spiritual intelligence and happiness, it was discovered that there was a significant relationship between spiritual intelligence and happiness (P <0.05), in a way that the increase of each one led to increase of the other one. Mean scores of happiness and spiritual intelligence did not have any significant relationship with sex, marital status, and age. However, different fields of academic disciplines had significant difference with respect to mean score of happiness. We discovered that surgery students got the highest happiness mean score (P-value <0.05). There was a significant relationship between the mean score of spiritual intelligence and different fields of academic disciplines (P-value = 0.044), but the mean score of spiritual intelligence could not lead to significant difference among different fields of academic disciplines. Conclusion: Higher spiritual intelligence was associated with higher levels happiness among university students. It seems that promotion of spiritual intelligence can lead to a cheerful mood and thus can improve the quality of provided care.