Introduction: cardiovascular disease are a major global concern regarding to their great burden. Coronary artery disease is a common cardiovascular disease which is mostly managed and diagnosed by angiography. As same as other cardiac interventions, angiography provide considerable stress and anxiety prior to its application. The aim of present study is the evaluation of premedication with benzodiazepine and aroma therapy in patients undergoing coronary angiograph. Material and methods: Patients who were candidate for coronary angiography enrolled in present clinical trial. These patients divided into 2 groups. The lavender group received lavender oil inhalation prior to angiography and other group received oxazepam the night before intervention. Changes in blood pressure and heart rate in both groups were then evaluated and analyzed by SPSS software version 20. Results: Among 80 patients with mean age of 49.9, a significant time effect for all variables indicating that the variables significantly changed over time regardless of the allocated group was seen. A significant difference in heart rate, SBP and DBP between baseline and at the end of the study (p<0.001) was observed but there was no significant difference between groups in terms of heart rate, SBP and DBP at baseline and at the end of the study (p>0.05). Conclusion: Although both treatment strategies can affect blood pressure and heart rate in patients undergoing coronary angiography, however, there is no superiority of using either of these two regimens in affecting blood pressure or heart rate.
