Microbial hydroxylation of dydrogesterone by Rhizopus stolonifer
Abstract
Microbial hydroxylation of dydrogesterone (9b,10a-pregna-4,6-diene-3,20-dione) (1) on fermentation with Rhizopus stolonifer afforded a new metabolite, 9b,12b-dihydroxy-9b,10a-pregna-4,6-diene-3,20-dione (2). Its structure was deduced on the basis of modern spectroscopic techniques.
