Background and Objective: Silybum marianum is one of the herbs which has been used in various studies. Therefore, this study aimed at investigating the effectiveness of Silymarin in relieving symptoms of migraine patients. Materials and Methods: In this study, 50 migraine patients diagnosed based on IHS scale and physician’s diagnosis were randomly assigned into two groups of intervention and control. For the intervention group, one 70mg Livergol tablet was administered per day in addition to the standard treatment (propranolol and nortriptyline), while the control group tow received the standard treatment. One and two months after initiation of the treatment, pain severity and disability in the patients was evaluated using Migraine Disability Assessment and Visual Analogue Scale questionnaires. The data were analyzed using SPSS and through independent t-test and repeated measure test. Findings: Average age of the participants in the intervention group was 38.16 8.8 years and in the control group, 39 12.24 years. Independent t-test showed that there was no significant difference between the control and intervention groups in terms of the main variables of the study (P>0.05). Repeated measure test showed that one and two months after the intervention, there was a significant difference between the control and intervention groups in the mean scores of pain severity and disability and also among the three measurements so that pain severity and disability were reduced and they were lower in the intervention group than those in the control group (P<0.001). Conclusion: Considering the results of this study, Silymarin can be used as a supplement in treatment of the migraine patients as it contains powerful antioxidants and does not have important side effects
