Background and purpose: Occupational stress is the most important factor in reducing the efficiency of organizations. Nurses as an important component of the health system, their important role in improving and Promotion community health, need to exact skill and concentration and strong teamwork in providing 24-hour care are exposed to many stressors and occupational stressors that affect physical and mental health and the quality of their work. Materials and methodology: The current research was a descriptive-cross sectional study. The census sampling method was performed on employed nurses in Emam Ali hospital different wards of Alborz Medical Sciences University with determining the amount effectiveness 9 stressors and their stressor rate in 2018. To collect data, HSS standard questionnaire (α= 84%) was utilized. Data were analyzed using SPSS 20 software, statistical methods [frequency distribution, mean, correlation tests (Pearson, Goodman and Kruskal), Chi-square and Fisher tests]. Results: The findings indicated that there was a positive relationship between occupational stress and age as well as job experience(P-Value = 0.05). Overall, 19% of samples didn`t have occupational stress and 81% had moderate stress. It indicated that most of the nurses of this center had experienced the stress in the moderate level. The highest stressors were increased workloads and fear of transferrable disease. Conclusion: According to the results of the study, managers and health authorities should have optimal planning for holding classes such as time management, infection control and training use of personal protective equipment appropriate, regular vaccination, nutrition and Personnel sleep to prevent decreased immunity and Decreased working hours of older and senior nurses.