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2018 Volume 9 Issue 2 Special Issue

Histomorphometric Study on the Effect of Propiconazole on Bone Growth Plate in Male Rats


Saeid Salahi*, Reza Ghazanfari, Akbar Darwish, Rasoul Mazloumshahraki, Yunes Shakibzade, Hadi Kord, Sahar Bahari
Abstract

Background and Purpose: Propiconazole is a systemic fungicide from the group of triazoles that is used to control a wide range of diseases. This poison causes the cellular, genetic and metabolic damage to the animals. The bone is a hard tissue that its contents are constantly changing. The longitudinal growth of the bone is due to the growth plate, which is a cartilaginous structure at the end of the long bones of the body. During sexual maturation, the growth of the growth plate stops the longitudinal growth of the bone. The purpose of this study was to evaluate the effect of propiconazole venom on growth plate expansion (including proliferation and hypertrophy cells) in immature rats.Materials and Methods: This experimental study was performed on 12 male Wistar rats randomly divided into two groups of control and propiconazole. Treatments were performed as oral gavage and for 28 days. On the 28th day, the animals were sacrificed and the left thigh bone was removed for histomorphometric study of the width of the thoracic appendix. The studies were performed by Rasband Wayne, 40g.1 ver, ImageJ, USA, NIH, and the results were significant by ANOVA ANOVA and test s'Tukey.Findings: Growth plaque width in the propiconazole group was significantly (P = 0.0626) less than that of the control group, which reduced the width of the reproductive area (P <0.001) and increased the width of the hypertrophied area (P=0/016).Results: Propiconazole Leads reduction of the width of the apple peptide growth plate in the immature rat rats and can be a factor in the disruption of the longitudinal growth pattern of the bone and the premature closure of the growth plate.


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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative