Background and objective: neonatal hyperbilirubinemia is one of the most common causes of hospitalization and it is one of the health problems around the world. As various centers adopt different methods in management of neonatal hyperbilirubinemia and the conditions for prescribing fluids and given the controversial results of studies conducted in this regard and as intravenous fluids in combination with phototherapy have been used routinely since several years ago for treatment of non-conjunctional non-hemolytic hyperbilirubinemia without special study in the neonatal unit of Shahid Motahari Hospital of Urmia, this research was conducted to evaluate the effect of prescription of intravenous fluids on non-hemolytic neonatal jaundice during phototherapy in the neonatal unit of Shahid Motahari Hospital in Urmia.Materials and Methods: In this clinical trial study, 120 neonates hospitalized due to jaundice were randomly assigned to control and intervention groups. In these two groups, the neonates were homogenized in terms of number, gender, age at hospitalization time, birth weight and weight at hospitalization time. The data were analyzed by using SPSS Version 21. Results: The mean of drop in bilirubin level at 6, 12 and 24 hours after phototherapy was not significantly different in the intervention group (received serum) and control group (did not receive serum). Additionally, the duration of phototherapy to achieve dischargeable bilirubin level (bilirubin under 13) was 38.8 hours in the intervention group and 41.31 hours in the control group, which was not significantly different.Conclusion: results of our study showed that there was no statistically significant difference between patients of intervention and control groups in terms of rate of reduction in bilirubin and the time required for phototherapy to discharge. According to the statistics, there was no significant difference between the two groups in rate and level of reduction in bilirubin at 6, 12, and 24 hours and the time required for phototherapy and the complications during phototherapy.
