Kahang Cu-Mo porphyry deposit in Isfahan is considered as one of the high potential deposits with the concentration of copper-molybdenum porphyry mineralization in surface and in depth given the severity, type and zonation of alterations as well as evidence of surface mineralization (oxide and leach cap), continuous geochemical anomaly (Cu-Mo ± Au), anomalies of magnetic geophysical index, induced polarization (IP) and resistivity (RS). Moreover, the 3-D modeling of IP / RS indicated the penetration of hydrothermal solutions coinciding with the presence of shear zones in the center of the deposit. In 3D modeling of the magnet, it was found that there is a magnetic mass in the south of the region with high permeability with extension to depth. As there were no calibrations of all the collected specimens, it was decided to use neural network method to estimate the grade in the non-calibrated specimens. For this purpose, a network with 5 inputs including sample spatial coordinates, chalcopyrite values and magnetic permeability were used. This network was run for the number of different neurons in the middle layer and finally the results of the network with 20 neurons in the middle layer were detected with respect to the RMS value for proper grade estimation. After estimating the sample grade, the deposit estimation was done. Initially, the statistical distribution of the data was analyzed and the data were transformed to the normal distribution. Then variography was performed to determine the main directions of anisotropy in the area. After determining the main directions of anisotropy, the optimal block dimensions were determined. In this way, jackknife kriging was used and finally blocks of 10 × 10 × 10 m were selected as optimal dimensions due to the low average relative error. Then using ordinary kriging, the 3-D copper grade estimation in the estimation space was performed. Estimation grade-tonnage diagram was plotted. According to these diagrams, the tonnage of Eastern Kahang deposit per grade cutoff 2500 ppm with ordinary kriging is 3437500 tons and its net copper content is 13750 tons with the same grade. Estimation grade-tonnage diagram was plotted. According to these diagrams, the tonnage of Eastern Kahang deposit per grade cutoff 2540 ppm with ordinary kriging of 3407500 tons and its net copper content is 13630 tons.