Background: Dressing is a pad applied directly to a wound in order to support the process of healing and protect the wound from further harm. The aim of this study was to compare the efficacy of nanocrystalline silver dressings as compared to conventional dressings in patients with injured, crushed fingers of the upper limbs.Materials and Methods: This single-blind study consisted of clinical trials. A total number of 70 patients with upper limb crushed fingers were studied. Patients were randomly divided into two groups – 35 patients were treated with nanocrystalline silver dressings and the remaining 35 patients with conventional dressings. We followed all patients during Weeks 1, 2, 3, and 4 after treatment, and checked degrees of healing for the wounds. Data were analyzed by SPSS20.Results: Degrees of healing for wounds with nanocrystalline silver dressings were more than that for wounds with conventional dressings in four stages. [Week 1: (p=0/011); Week 2 (p=0/000); Week 3 (p=0/051); and Week 4: (0/003)]. There was a significant difference in infection in Week 1 (p=0/04) and Week 2 (p=0/052) between both groups. There was also a significant difference in inflammation in Week 1 and Week 2 between the two groups (p< 0/05); as well as a significant difference in itching in Week 1 and Week 2 between the groups (p< 0/05).Conclusion: Nanocrystalline silver dressings lead to an improvement in the degree of wound healing, and reduce infection, inflammation, and itching. Hence, we recommended nanocrystalline silver dressings for patients.