The aim of present study is education effect of stress management in cognitive manner – a behavior on coping styles of female nurses of Imam Ali hospital of Zarand. In this semi-test study, 40 female nurses was selected as sample and then was put two groups with 20 people (test and evidence). After doing pre-test, test group put into education of stress management in cognitive– behavioral manner. Then post-test in both groups administered by questionnaire of coping responses of Billkis (1981). It was used from SPSS software and dependent T test to analyses data. Results showed that education of stress management in cognitive – behavioral manner has a significant effect on coping styles of female nurses (p < 0.01) and has caused to improve behavioral, cognitive, issue – driven coping styles. So, it is proposed that administration and continuity of stress management education in cognitive – behavioral manner paying attention to treatment responsible to improve coping styles of female nurses.