Cornelian cherry (cornus mass l.) is a fruit widely distributed in Europe, Turkey and some regions of Iran. Since this fruit is a main source of phytochemicals such as tannins, phenols, organic acids, anthocyanins, quercetin, kaempferol and aromadendrin, different studies focused on medicinal effect of the fruit on multiple disorders. This review accumulates some results from previous studies worked on this fruit. Cornelian mas extraction showed some anti cancer function in vitro due to its antioxidant capacity. Furthermore several studies observed beneficial effects of the fruit on dyslipidemia that result in lower total cholesterol, TG, LDL-cholesterol and some improvements in HDL cholesterol levels that could be related to its rich anthocyanins content by stimulation of PPARα expression. Another property of this fruit is its potential to modulate glycemic profile by increasing insulin secretion from B cell, improve glucose uptake by phosphorylation of insulin receptors, inhibition of α-glucosidase, postpone carbohydrate hydrolysis and activate G protein receptors due to high polyphenols content. Overall, different studies showed therapeutics effects of the fruit, so it can be used for further studies in future.
