Introduction and Objectives: Today, a large number of people visit the dental clinics with anxiety and this is significantly increasing. It seems that the origin of this anxiety is the negative experience of people in the past which is the most important reason for the emergence of this fear and anxiety from dentistry. Therefore, in this study, the reduction in anxiety was compared through medication and giving awareness and relaxation to patients visiting the dental clinic. Method: In this study, 80 patients visiting the Department of Periodontics of the dentistry faculty were divided equally between men and women into three groups: group A (anxiety reduction with diazepam), group B (reduction of anxiety by giving awareness and relaxation) and group C (anxiety reduction with Placebo). In each group, the anxiety level of the patients was compared before and after the anxiety reduction protocol. Results: In this study, it was found that in group B, which their anxiety decreased by giving awareness and relaxation, the average of anxiety before and after reduction protocol was 50.23 and 18.88, respectively, showed by P<0.001. Conclusion: Regarding the importance of decreasing anxiety in patients visiting the dental clinics, the necessity of knowledge of the patients about dentistry, and considering this study, the method of giving awareness and relaxation, in comparison with other methods, has a higher percentage in reducing anxiety.