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2015 Volume 6 Issue 1

The role of carboxyl esterase and acid phosphatase in aged and lithium treated rats in regulation of neuronal function


Abstract
Acid Phosphatase (ACP) and Carboxyl Esterase (CE) wereassayed for four different groups of young and old aged maleAlbino Sprague dawley rats (2-4 and 16-18 months) in brain andliver. Among them both aged rats were treated with 37 mg oflithium chloride (LiCl2) per kilogram of body weight orally for 10days. LiCl2 showed completely positive effect on releasingcarboxyl esterase in both young and old groups of brain (36.1 and89.3 nmoles/min/mg of protein) and liver (114.93 and 91.73nmoles/min/mg of protein) respectively than control. The youngand old rat brain samples treated with LiCl2 showed intense bandfor CE in Native PAGE gel than untreated groups. Acidphosphatase showed more activity in normal young rats than oldaged rats however, old rats treated with LiCl2 showed moresignificant ACP activity (65.3 nmoles/min/mg of protein) andyoung rats showed elevated ACP activity (55.1 nmoles/min/mg ofprotein) respectively than untreated groups. Thus LiCl2 isinvolved in activation of enzymatic function and potential to beintegrated into drug-development programs complexed with CEneuroprotective factor to facilitate the neuronal function.

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JOURNAL OF BIOCHEMICAL TECHNOLOGY
JOURNAL OF BIOCHEMICAL TECHNOLOGY
Journal of Biochemical Technology is a peer reviewed International Journal published by the Sevas Publishing on behalf of the Biochemical Technology Society, a Registered Charity Organization from India

AREA OF INTEREST
AREA OF INTEREST
Areas of high interest, cover new advances in enzymatic and protein mechanims; applied molecular genetics and biotechnology; genomics and proteomics; metabolic; medical, environmental, food and agro biotechnology.

FOCUS AND SCOPE
FOCUS AND SCOPE
Journal Of Biochemical Technology” Provides A Medium For The Rapid Publication Of Full-Length Articles, Mini-Reviews Of New And Emerging Products And Short Communications On All Aspects Of ...

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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Keywords include, Biochemical Research: Endo/exocytosis, Trafficking, Membrane Biology, Cell Migration, Cell-Matrix Organelle Biogenesis, Cytoskeleton Proteolysis, Cell Death, Cell Cycle, Cancer, Cell Growth/Death, Differentiation, Drug Targets, Gene Therapy, Models of Disease, Proteomics, Stem Cells, Bioenergetics, Mitochondria, Free Radicals, Redox Signaling, Ion Transport/Channels, Oxidative