TY - JOUR T1 - Prenatal Diagnosis of Preeclampsia by Molecular of Circulating Corticotrophin-Releasing Hormone and Ep mRNA of Placental in Maternal Plasma A1 - Kobra Hamdi A1 - Noushin Mobaraki Asl* A1 - Farzaneh Sadeghi A1 - Parvin Hakimi A1 - Faranak Jalilvand JF - Journal of Biochemical Technology JO - J Biochem Technol SN - 0974-2328 Y1 - 2018 VL - 9 IS - 2 SP - 178 EP - 184 N2 - Objective: Preeclampsia (PE) is a common disorder in pregnancy. Corticotrophin-releasing hormone (CRH)ats through vasodilatory effects. The aim of this study is diagnosis of PE by molecular of circulating CRH and Ep mRNA of placental in maternal plasma. Material and methods: The study was performed in early pregnant women with  PE (n= 28) and normal pregnant women (n=30) as control group, blood samples was taken from each mother. Total RNA was isolated from harvested plasma synthesized from RNA samples using reverse transcription kit (Gen net bio) by the instructions of the manufacturer. Results: The Results indicated that expression of CRH was significantly different amongwomen suffered from preeclamptic compare of healthy pregnant women.  Conclusion: This study demonstrated that thosemRNA concentrations were increased in the plasma of PE patients compared with those of normalsubjects and suggest the opportunity to gain furtherinsight into pathological pregnancy through mRNA measurementsin maternal plasma.  UR - https://jbiochemtech.com/article/prenatal-diagnosis-of-preeclampsia-by-molecular-of-circulating-corticotrophin-releasing-hormone-and-ep-mrna-of-placental-in-maternal-plasma ER -